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Letybo in Covington, KYThe Newest FDA-Approved Neurotoxin for Frown Lines

Treatment Time:
10-15 minutes
Downtime:
None
Results Last:
3-4 months
FDA Approved:
Yes, 2024
Patient receiving a Letybo injection between the brows at Applegate Dentistry and MedSpa in Covington, KY

Advanced Injectables

Letybo Injections, Explained From Zero

Letybo in Covington, KY is a newer FDA-approved neurotoxin used to soften the moderate to severe frown lines that form between the brows. Patients travel to us from across Kenton County, Northern Kentucky and Cincinnati, OH, including Newport, Fort Mitchell and Edgewood. If you keep hearing the name without knowing what it actually is, you are far from alone.

Letybo injections at Applegate MedSpa are placed by Elizabeth Taylor, APRN, who brings a background in acute care medicine plus advanced training with the American Academy of Facial Esthetics. She works alongside Dr. Barry Applegate, DMD, whose three decades reading facial and jaw anatomy in Covington shape how our team maps every injection point.

Close view of glabellar frown lines before and after Letybo treatment at Applegate MedSpa in Covington, KY

The Challenge

When Frown Lines Stay Put, Letybo Helps

Understanding Dynamic Lines

You concentrate, you squint at a screen, you step into the sun, and two vertical lines pull in between your brows. For years they smoothed out again. Now they are still there in the mirror at the end of the day, and in photographs where you thought you looked relaxed. Patients tell us the frown line is the feature people misread: colleagues ask if something is wrong, family asks if you are annoyed, and you were simply thinking.
Letybo relaxes the two small muscle groups responsible for that pull, the corrugators that draw the brows inward and the procerus at the bridge of the nose. With the pull eased, the skin above stops folding along the same crease and gradually settles smoother. Movement softens rather than disappears, so you still raise your brows and still look like yourself. Most patients notice the change within a few days and see the full effect by about week four.

Understanding Your Treatment

What Is Letybo and How Does It Work?

The Science of Botulinum Toxin

Letybo is letibotulinumtoxinA-wlbg, a botulinum toxin type A from Hugel, FDA approved in 2024. Its approval covers one thing: moderate to severe glabellar lines, the vertical frown lines between the brows. It is a narrower approved use than Botox carries, and we say so up front.

Letybo blocks the nerve signal that tells a muscle to contract, the mechanism behind every botulinum toxin type A product. Ease the corrugator and procerus muscles and the skin above them stops folding. The labeled dose is four units at each of five points, 20 units total, repeated no more often than every three months. Letybo is one of three type A neurotoxins at our Covington practice, alongside Botox and Jeuveau, and Elizabeth compares all three with you before anything is injected.

Treatment Timeline:

First Signs:
2 to 3 days (early softening)
Full Effect:
About 4 weeks (peak)
Treatment Time:
10 to 15 minutes (per visit)
Recovery:
None needed

Your Experience

What Happens During a Letybo Treatment

Step-by-Step Process

  1. Mapping

    Elizabeth watches you frown and marks the corrugator and procerus injection points.

  2. Preparation

    She cleanses the glabellar area and offers ice or topical numbing cream if you want it.

  3. Injection

    Five small injections go in with a fine 30-gauge needle, usually finished in under two minutes.

  4. Aftercare

    Elizabeth reviews the stay-upright and do-not-rub rules and sets your two-week check-in.

What Letybo Treats

Letybo Treatment Areas

Focused on the Upper Face

Soft magenta and plum gradient background representing calm, relaxed facial expression after Letybo treatment

  • Glabellar Frown Lines

    The FDA-approved use: the vertical 11 lines between the brows

  • Corrugator Pull

    Softens the muscles that draw your brows inward when you focus

  • Procerus Tension

    Eases the muscle at the bridge of the nose that pulls downward

  • A Stern Resting Look

    Relaxes the crease that reads as frustration when you are calm

  • Early Etched Creases

    Helps lines that are starting to stay visible without movement

  • Preventative Softening

    Some patients start early to keep frown lines from deepening

Benefits of Letybo Injections

Precise and Predictable

Newest FDA ApprovalFDA approved in 2024 after three phase 3 clinical trialsFocused IndicationApproved specifically for moderate to severe frown linesShort AppointmentMost Letybo visits run 10 to 15 minutes start to finishResults Build QuicklySoftening in 2 to 3 days, with peak effect near week 4Lower Per-Unit PriceLetybo is $10 per unit at our Covington office, Botox is $12

Letybo vs. Other Frown Line Options

Letybo, Botox, Emface, fillers and retinoids work through different mechanisms. Here is how they line up for frown lines.

TreatmentMechanismTimeResultsDurationDowntimeBest For
LetyboBotulinum toxin type A10-15 minutesSmoother frown lines3-4 monthsNoneModerate to severe 11 lines
BotoxBotulinum toxin type A10-15 minutesSmoother upper face3-4 monthsNoneBroader approved areas
JeuveauBotulinum toxin type A10-15 minutesSmoother frown lines3-4 monthsNoneFrown lines with onset as early as day 2
EmfaceHIFES plus radiofrequency20 minutesLifted, toned skinUp to a yearNoneNeedle-free facial toning
Dermal fillersInjectable volume30-45 minutesRestored contour6-18 months1-3 days bruisingStatic volume loss
Topical retinoidsFaster cell turnoverDaily at homeGradual texture changeWhile in usePeeling, drynessFine surface lines

Is This Right for You

Who Is a Good Candidate for Letybo?

Finding Your Best Fit

Letybo suits adults bothered by the vertical frown lines between the brows who want a treatment with a clear, focused FDA approval behind it.

Ideal Candidates for Letybo

  • Adults 18 and older with moderate to severe glabellar lines
  • Patients trying a neurotoxin for the first time who prefer a newer, well-studied option
  • Anyone tracking wrinkles and fine lines who wants to start with the frown area
  • People in good general health with realistic expectations about softening rather than erasing a line
  • Patients willing to return roughly every three to four months to hold the result

Who Should Wait or Avoid Letybo

  • Anyone pregnant or breastfeeding
  • Patients with a known hypersensitivity to any botulinum toxin product or its components
  • People with an active skin infection at the planned injection site
  • Patients with myasthenia gravis, Lambert-Eaton syndrome or ALS, where toxin effects may spread more readily
  • Anyone taking aminoglycoside antibiotics or other agents that interfere with neuromuscular transmission, until their physician clears it

If needles are not for you, needle-free facial toning with Emface works the upper face without injections. Absolute contraindications are reviewed at every consultation before a single unit is drawn.

Risks and Side Effects

What to Know

The Applegate Difference

Why Choose Applegate MedSpa for Letybo in Covington, KY

Covington's Nurse Practitioner Led Team

Dr. Barry Applegate, DMD has spent more than three decades reading facial and jaw anatomy in Covington, and that lens shapes how our team approaches injectables. Elizabeth Taylor, APRN places every Letybo dose with the same anatomical map in mind, so the result reads as rested rather than frozen.

Book a Consultation

  • Facial Anatomy Expertise

    Facial and jaw expertise informs every injection point we map

  • Experienced Injector

    Elizabeth Taylor, APRN, board-certified nurse practitioner

  • Honest Product Advice

    We explain where Letybo fits and where it does not apply

  • Trusted Locally

    Rated 4.9 from 771 Google reviews across our Covington practice

  • $10 Per Unit

    The FDA labeled 20 unit frown line dose lands near $200

  • Two Week Check In

    Every treatment is followed by a review so the next dose is mapped to your result

Investment

How Much Letybo Costs in Covington, KY

Pricing and Payment Options

How Much Does Letybo Cost in Covington, KY?

Letybo is $10 per unit at Applegate MedSpa. The FDA-labeled dose for frown lines is 20 units, which puts a standard glabellar treatment near $200, though your own dose depends on muscle strength and how deeply the lines are set.

ProductPrice Per Unit
Letybo$10
Botox$12

Why a Lower Unit Price Is Not Automatically a Lower Bill

Units are not interchangeable between botulinum toxin products, and the number you need depends on your anatomy and the area being treated. A lower price per unit only produces a lower total when the unit count is similar, so we quote the whole treatment rather than the sticker price. If you are weighing the two products, read Letybo vs Botox: a full comparison, or browse the full range of injectable treatments in Covington.

Flexible Payment Options

We want the plan to fit your budget, not the other way around.

  • Cherry Financing - monthly payment plans with a quick approval process and options for a range of credit profiles.
  • Major credit cards - accepted for a single session or a full series.
  • HSA and FSA - health spending account funds are accepted where your plan administrator allows the treatment, so check your plan first.

Promotional pricing available at consultation. Call to schedule a free consult.

Patient receiving Botox injections in the forehead area at Applegate Dentistry and MedSpa in Covington, KY

Related Treatment

Botox

Injectable onabotulinumtoxinA that relaxes the muscles behind your expression lines for a rested, natural look.

  1. Fast Appointment
  2. No Downtime
  3. Natural Movement
Learn More

Related Treatment

Jeuveau

An FDA approved frown line neurotoxin with results that can start by day two.

  1. Fast Onset
  2. Fifteen Minute Visit
  3. No Downtime
Learn More

Related Treatment

Emface

Needle free facial lifting

  1. No Needles
  2. Zero Downtime
  3. Muscle and Skin
Learn More

Related Treatment

RF Microneedling with Exion

Fractional radiofrequency delivered through fine needles to firm skin, refine pores and smooth texture.

  1. Your Own Collagen
  2. Multiple Concerns
  3. Short Recovery
Learn More

Common Questions

Frequently Asked Questions About Letybo

How much does Letybo cost in Covington, KY?
Letybo is $10 per unit at Applegate MedSpa. The FDA-labeled dose for frown lines is 20 units, so a standard glabellar treatment lands near $200. Your actual dose depends on muscle strength and how deeply the lines are set, so we confirm the unit count and the full price before we draw anything. Cherry Financing is available.
How long does Letybo last?
Most patients keep their result for three to four months. Movement returns gradually rather than all at once, so frown lines reappear slowly as the effect fades. Repeat treatment is labeled for no more often than every three months. Elizabeth tracks your timing across visits so your appointments settle into a rhythm that suits your face.
Does Letybo hurt?
Most patients describe it as a quick pinch rather than pain. The needle is very fine and only five small injections are needed for the frown area, so the whole thing is over in about two minutes. Ice or a topical numbing cream is available if you prefer. Tenderness afterward is mild and usually gone the same day.
When will I see results from Letybo?
Many patients notice softening within two to three days. The full effect typically shows around week four, which is when we like to see you for a check-in. If a small area still pulls, that visit is the moment to refine it. Individual timing varies with metabolism, muscle strength and how many treatments you have had before.
How often do I need Letybo treatments?
Plan on three to four treatments per year. The product label allows repeat dosing no more frequently than every three months, and most patients settle into a schedule around that mark. Some people find their results hold slightly longer after several consistent rounds. We book your next visit before you leave so the effect does not fully lapse.
How is Letybo different from other neurotoxins?
Letybo is letibotulinumtoxinA, approved by the FDA in 2024 specifically for moderate to severe frown lines. Other neurotoxins carry broader approved areas and longer track records in the US market. Units are not interchangeable between products. For a full side-by-side look at the two options, read our article on how the two compare before your consultation.
Can men get Letybo?
Yes. Men are a growing share of neurotoxin patients, and the frown line is often the first thing they want addressed. Male corrugator muscles tend to be stronger, so men frequently need a higher unit count than women for the same area. Elizabeth adjusts dosing to muscle strength rather than to a standard template.
Is Letybo FDA approved for forehead lines or crow's feet?
No. Letybo's FDA approval covers moderate to severe glabellar lines, the vertical frown lines between the brows, in adults. That is a narrower indication than some other neurotoxins carry. We will say so honestly at your consultation and talk through the options if your main concern sits elsewhere on the face.
Who injects Letybo at Applegate MedSpa?
Elizabeth Taylor, APRN performs our injectable treatments. She is a board-certified nurse practitioner with a background in acute care medicine, and she completed advanced aesthetics training with the American Academy of Facial Esthetics. Dr. Barry Applegate, DMD contributes the facial and jaw anatomy expertise behind our approach.
Can I combine Letybo with other treatments?
Often, yes. Letybo addresses movement lines, while treatments such as Emface work on muscle tone and skin quality without needles. Many patients pair the two to cover both. Spacing matters, so we plan the order and timing of each treatment together at your consultation rather than stacking everything into one visit.
Letybo or Jeuveau, which one should I choose?
Letybo and Jeuveau are both botulinum toxin type A approved for frown lines, and both are priced per unit at our Covington practice. Letybo is letibotulinumtoxinA, approved by the FDA in 2024, and it is our lowest unit price. Jeuveau is prabotulinumtoxinA-xvfs, approved in 2019, and it starts working as early as day two. If the lowest unit price matters most, Letybo is usually the answer. If you have an event coming up and want the fastest start, Jeuveau usually is. Elizabeth goes through both at your consultation.
Location322 Greenup StCovington, KY, 41011Phone(859) 365-3300Emailinfo@applegatemedspa.com

Schedule Today Your Letybo Consultation

References

  1. Masood M et al., Aesthetic Plastic Surgery. (2026). A systematic review and meta-analysis of RCTs found letibotulinumtoxinA efficacious and well tolerated for moderate-to-severe glabellar lines. PMID: 41501424.
  2. Cox SE et al., Dermatologic Surgery. (2024). LetibotulinumtoxinA attenuated the psychological burden of glabellar lines and was associated with high subject satisfaction in phase 3 clinical trials. PMID: 38470985.
  3. Gold M et al., Aesthetic Surgery Journal Open Forum. (2024). Post hoc analyses of phase 3 clinical study data supported the efficacy and safety of letibotulinumtoxinA in moderate and severe glabellar lines in females 35 to 50 years of age. PMID: 38486835.
  4. Choi HS et al., Plastic and Aesthetic Nursing. (2024). Consensus recommendations for treatment of the upper face with letibotulinumtoxinA. PMID: 39348312.
  5. Zargaran D et al., Aesthetic Surgery Journal. (2022). A systematic review and meta-analysis quantified complications of cosmetic botulinum toxin A injections to the upper face. PMID: 35178552.
  6. U.S. Food and Drug Administration. (2024). Letybo (letibotulinumtoxinA-wlbg) prescribing information, approved for moderate to severe glabellar lines in adults.
  7. Hugel, Letybo product information. (2024). Manufacturer overview of letibotulinumtoxinA-wlbg presentation and handling.
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